Cluster | Total UMI counts | Global CPM | Transcripts | Categories | Human homolog | Annotation |
---|---|---|---|---|---|---|
MligTC455_45263 | 126 | 2.63 | Mlig455_007141 | Neo: - Age: - |
Mlig455_007141 {REF} {Length: 2891} {Smed: dd_Smed_v6_5091_0_1, dd_Smed_v6_5091_0_1, [Score=133, Expect=1e-35]} {RNA1509_54868} {RNA1310_9306} {RNA815_2941.1} |
Region | logFC | logCPM | Pvalue | FDR | Specificity |
---|---|---|---|---|---|
RegionR1 | 1.344 | 2.349 | 0.59405 | 1.00000 | |
RegionR2 | -3.195 | 2.349 | 1.00000 | 1.00000 | |
RegionR3 | 1.039 | 2.349 | 0.23704 | 0.77838 | |
RegionR4 | 1.721 | 2.349 | 0.09679 | 0.30057 | |
RegionR5 | 0.323 | 2.349 | 0.63744 | 0.98992 | |
RegionR6 | 1.195 | 2.349 | 0.18292 | 0.74785 | |
RegionR7 | 1.509 | 2.349 | 0.17865 | 0.77438 | |
RegionR8 | -3.936 | 2.349 | 0.27549 | 0.89981 |
Region | logFC | logCPM | PValue | FDR | Specificity |
---|---|---|---|---|---|
RegenerationR1 | -6.009 | 2.349 | 0.34196 | 1.00000 | |
RegenerationR2 | 0.481 | 2.349 | 0.62752 | 0.92610 | |
RegenerationR3 | -0.402 | 2.349 | 0.57187 | 0.89501 | |
RegenerationR4 | 0.332 | 2.349 | 0.72057 | 0.96161 | |
RegenerationR5 | 0.474 | 2.349 | 0.53119 | 0.87566 | |
RegenerationR6 | 0.115 | 2.349 | 0.89322 | 1.00000 | |
RegenerationBL | -5.006 | 2.349 | 0.99970 | 1.00000 | |
RegenerationTP | 0.805 | 2.349 | 0.64351 | 0.98519 |
Nr. | Cluster | Total UMI counts | Global CPM | Transcripts | Categories | Human homolog | Σ Spearman correlations | Int1 | Int2 | Int3 | Reg1 | Reg2 | Reg3 | Annotation |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1. | MligTC455_45263 | 126 | 2.63 | Mlig455_007141 | Neo: - Age: - |
6 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | 1.000 | Mlig455_007141 {REF} {Length: 2891} {Smed: dd_Smed_v6_5091_0_1, dd_Smed_v6_5091_0_1, [Score=133, Expect=1e-35]} {RNA1509_54868} {RNA1310_9306} {RNA815_2941.1} | |
2. | MligTC455_27958 | 907 | 18.9 | Mlig455_027301 | Neo: - Age: Down-Up-Up Region-enriched R6: 1.674/0.00384 |
SLC6A1 | 1.852 | - | - | - | 0.894 | 0.958 | - | Mlig455_027301 {REF} {Length: 2723} {Pfam: Sodium:neurotransmitter symporter family [PF00209.20, score=127.1]} {Human: ENSG00000157103, SLC6A1, solute carrier family 6 member 1, [Score=106, Expect=2e-23]} {Mouse: ENSMUSG00000030310, Slc6a1, solute carrier family 6 (neurotransmitter transporter, GABA), member 1, [Score=103, Expect=8e-23]} {Dmel: FBgn0011603, ine, inebriated, [Score=112, Expect=2e-25]} {Celegans: WBGene00000934, dat-1, Sodium-dependent dopamine transporter, [Score=81.6, Expect=5e-16]} {Smed: dd_Smed_v6_7447_0_1, dd_Smed_v6_7447_0_1, [RH, Score=424, Expect=3e-142]} {RNA1509_1953} {RNA1310_10042.1} {RNA815_3754.1} |
3. | MligTC455_37108 | 55 | 1.15 | Mlig455_017782, Mlig455_067562, Mlig455_068769 | Neo: - Age: logFC(26M/2M)=-1.834 |
1.845 | - | - | 0.952 | 0.893 | - | - | Mlig455_017782 {REF} {Length: 3096} {TRANSSPLICED} {RNA1509_27316} {RNA1310_5077} {RNA815_5595} Mlig455_067562 {REF} {Length: 2108} {Pfam: ATPase family associated with various cellular activities (AAA) [PF00004.31, score=20.5]; AAA domain [PF13401.8, score=19.4]} {RNA1509_27316} {RNA1310_5077} {RNA815_5595} Mlig455_068769 {REF} {Length: 485} {Pfam: ATPase family associated with various cellular activities (AAA) [PF00004.31, score=24.7]; AAA ATPase domain [PF13191.8, score=20.7]; AAA domain [PF13401.8, score=20.0]; AAA domain [PF13671.8, score=19.4]} {RNA1509_27316} {RNA1310_5077} {RNA815_5595} |
|
4. | MligTC455_32319 | 1579 | 32.9 | Mlig455_065963 | Neo: - Age: - Region-enriched R4: 1.893/0.00270 |
CTSA | 1.834 | - | - | - | 0.882 | 0.952 | - | Mlig455_065963 {REF} {Length: 1899} {TRANSSPLICED} {Pfam: Serine carboxypeptidase [PF00450.24, score=405.7]} {Human: ENSG00000064601, CTSA, cathepsin A, [RH, Score=417, Expect=1e-141]} {Mouse: ENSMUSG00000017760, Ctsa, cathepsin A, [RH, Score=425, Expect=1e-144]} {Dmel: FBgn0038738, CG4572, [Score=108, Expect=4e-25]} {Celegans: WBGene00019605, ctsa-1, Uncharacterized serine carboxypeptidase ctsa-1, [RH, Score=339, Expect=1e-111]} {Smed: dd_Smed_v6_785_0_1, dd_Smed_v6_785_0_1, [RH, Score=392, Expect=3e-132]} {RNA1509_366, RNA1509_39936} {RNA1310_10272.1, RNA1509_39936} {RNA1509_39936, RNA815_3612.1} |
5. | MligTC455_38076 | 351 | 7.3 | Mlig455_038503, Mlig455_052250, Mlig455_052295 | Neo: - Age: Down-Down-Up Region-enriched R4: 3.194/0.03208 |
1.747 | - | - | - | 0.956 | 0.791 | - | Mlig455_038503 {REF} {Length: 2297} {RNA1509_18000} {RNA1310_14098} {RNA815_2224.1} Mlig455_052250 {REF} {Length: 2585} {Pfam: Zona pellucida-like domain [PF00100.25, score=47.2]; Scavenger receptor cysteine-rich domain [PF00530.20, score=43.8]} {RNA1509_18000, RNA1509_39101, RNA1509_59160} {RNA1310_14098, RNA1509_18000, RNA1509_39101, RNA1509_59160} {RNA1509_18000, RNA1509_39101, RNA1509_59160, RNA815_2224.1} Mlig455_052295 {REF} {Length: 2314} {Pfam: Zona pellucida-like domain [PF00100.25, score=47.4]; Scavenger receptor cysteine-rich domain [PF00530.20, score=40.3]} {RNA1509_18000} {RNA1310_14098} {RNA815_2224.1} |
|
6. | MligTC455_18225 | 657 | 13.69 | Mlig455_034956 | Neo: - Age: logFC(26M/2M)=0.287 |
1.721 | - | - | - | 0.966 | - | 0.755 | Mlig455_034956 {REF} {Length: 2635} {Pfam: Arrestin (or S-antigen), N-terminal domain [PF00339.31, score=45.3]; Arrestin (or S-antigen), C-terminal domain [PF02752.24, score=40.0]} {Dmel: FBgn0037518, CG2641, [Score=52.4, Expect=4e-07]} {Celegans: WBGene00012464, arrd-7, ARRestin Domain protein, [Score=54.7, Expect=5e-08]} {RNA1509_22116} {RNA1310_8444.1, RNA1509_22116} {RNA1509_22116, RNA815_2910} | |
7. | MligTC455_33518 | 74 | 1.54 | Mlig455_034081 | Neo: - Age: - |
SLC5A9 | 0.973 | - | - | - | 0.973 | - | - | Mlig455_034081 {REF} {Length: 2394} {Pfam: Sodium:solute symporter family [PF00474.19, score=357.0]} {Human: ENSG00000117834, SLC5A9, solute carrier family 5 member 9, [RH, Score=545, Expect=0.0]} {Mouse: ENSMUSG00000028544, Slc5a9, solute carrier family 5 (sodium/glucose cotransporter), member 9, [Score=556, Expect=0.0]} {Dmel: FBgn0039872, salt, salty dog, [Score=85.1, Expect=8e-17]} {Smed: dd_Smed_v6_6663_0_1, dd_Smed_v6_6663_0_1, [Score=506, Expect=7e-172]} {RNA1509_13834} {RNA1310_9462} {RNA815_5775} |
8. | MligTC455_50645 | 44 | 0.91 | Mlig455_036533 | Neo: - Age: - |
SCYL1 | 0.972 | - | - | - | - | 0.972 | - | Mlig455_036533 {REF} {Length: 4260} {TRANSSPLICED} {Pfam: HEAT repeat [PF02985.24, score=41.4]; non-SMC mitotic condensation complex subunit 1 [PF12717.9, score=37.1]; HEAT repeats [PF13646.8, score=32.6]; Protein tyrosine and serine/threonine kinase [PF07714.19, score=25.7]; Protein kinase domain [PF00069.27, score=23.0]} {Human: ENSG00000142186, SCYL1, SCY1 like pseudokinase 1, [RH, Score=447, Expect=7e-145]} {Mouse: ENSMUSG00000024941, Scyl1, SCY1-like 1 (S. cerevisiae), [RH, Score=441, Expect=6e-143]} {Dmel: FBgn0260990, yata, [RH, Score=516, Expect=4e-171]} {Celegans: WBGene00012337, W07G4.3, [RH, Score=404, Expect=6e-129]} {Smed: dd_Smed_v6_3470_0_1, dd_Smed_v6_3470_0_1, [RH, Score=460, Expect=5e-152]} {RNA1509_21531, RNA1509_23084, RNA1509_58473} {RNA1310_4140, RNA1509_21531, RNA1509_23084, RNA1509_58473} {RNA1509_21531, RNA1509_23084, RNA1509_58473, RNA815_4060} |
9. | MligTC455_29292 | 133 | 2.78 | Mlig455_009596, Mlig455_027057 | Neo: - Age: - |
ANK2, TNKS2 | 0.967 | - | - | - | 0.967 | - | - | Mlig455_009596 {REF} {Length: 3012} {TRANSSPLICED} {Pfam: Ankyrin repeats (3 copies) [PF12796.9, score=142.2]; Ankyrin repeats (many copies) [PF13637.8, score=107.1]; Ankyrin repeat [PF00023.32, score=100.6]; Ankyrin repeat [PF13606.8, score=95.6]; Ankyrin repeats (many copies) [PF13857.8, score=89.9]} {Human: ENSG00000107854, TNKS2, tankyrase 2, [Score=94.4, Expect=5e-20]; ENSG00000145362, ANK2, ankyrin 2, [Score=92.4, Expect=2e-19]} {Mouse: ENSMUSG00000024811, Tnks2, tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, [Score=94.0, Expect=4e-20]; ENSMUSG00000032826, Ank2, ankyrin 2, brain, [Score=92.4, Expect=2e-19]} {Dmel: FBgn0261788, Ank2, Ankyrin 2, [Score=97.8, Expect=2e-21]} {Celegans: WBGene00006780, unc-44, AO66 ankyrin, [Score=87.0, Expect=4e-18]} {Smed: dd_Smed_v6_10835_0_1, dd_Smed_v6_10835_0_1, [Score=86.7, Expect=5e-18]} {RNA1509_27393} {RNA1310_17845.1} {RNA815_7253} Mlig455_027057 {REF} {Length: 3188} {TRANSSPLICED} {Pfam: Ankyrin repeats (3 copies) [PF12796.9, score=140.6]; Ankyrin repeats (many copies) [PF13637.8, score=109.4]; Ankyrin repeat [PF00023.32, score=100.3]; Ankyrin repeat [PF13606.8, score=95.6]; Ankyrin repeats (many copies) [PF13857.8, score=88.9]} {Human: ENSG00000145362, ANK2, ankyrin 2, [Score=93.2, Expect=1e-19]; ENSG00000107854, TNKS2, tankyrase 2, [Score=92.0, Expect=3e-19]} {Mouse: ENSMUSG00000032826, Ank2, ankyrin 2, brain, [Score=93.2, Expect=1e-19]; ENSMUSG00000024811, Tnks2, tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase 2, [Score=91.7, Expect=2e-19]} {Dmel: FBgn0261788, Ank2, Ankyrin 2, [Score=95.9, Expect=8e-21]} {Celegans: WBGene00006780, unc-44, AO66 ankyrin, [Score=87.0, Expect=4e-18]} {Smed: dd_Smed_v6_10835_0_1, dd_Smed_v6_10835_0_1, [Score=87.8, Expect=2e-18]} {RNA1509_27393} {RNA1310_17845.1} {RNA815_7253} |
10. | MligTC455_41793 | 128 | 2.66 | Mlig455_056389 | Neo: - Age: logFC(26M/2M)=-0.406 |
CCDC96 | 0.963 | - | - | - | - | 0.963 | - | Mlig455_056389 {REF} {Length: 2189} {Pfam: Domain of unknown function (DUF4201) [PF13870.8, score=154.7]} {Human: ENSG00000173013, CCDC96, coiled-coil domain containing 96, [RH, Score=195, Expect=5e-54]} {Mouse: ENSMUSG00000050677, Ccdc96, coiled-coil domain containing 96, [RH, Score=195, Expect=4e-54]} {Smed: dd_Smed_v6_9313_0_1, dd_Smed_v6_9313_0_1, [RH, Score=201, Expect=5e-59]} {RNA1509_26742, RNA1509_58369} {RNA1310_8172.1, RNA1509_58369} {RNA1509_58369, RNA815_3762} |
11. | MligTC455_15192 | 354 | 7.37 | Mlig455_053640 | Neo: Germline Age: - Region-specific R4: 4.285 Region-enriched R4: 2.480/0.00000 Regeneration-downregulated R4: -1.962 Regeneration-depleted R4: -1.962 |
RAB26 | 0.96 | - | - | - | 0.960 | - | - | Mlig455_053640 {REF} {Length: 3489} {Pfam: Ras of Complex, Roc, domain of DAPkinase [PF08477.15, score=54.9]; Ras family [PF00071.24, score=40.8]; AAA domain [PF13401.8, score=20.3]} {Human: ENSG00000167964, RAB26, RAB26, member RAS oncogene family, [Score=50.8, Expect=1e-06]; ENSG00000144134, RABL2A, RAB, member of RAS oncogene family like 2A, [Score=50.1, Expect=2e-06]} {Mouse: ENSMUSG00000022621, Rabl2, RAB, member RAS oncogene family-like 2, [Score=52.8, Expect=1e-07]} {Dmel: FBgn0086913, Rab26, [Score=52.0, Expect=4e-07]} {Celegans: WBGene00004266, rab-1, RAB family, [Score=48.5, Expect=2e-06]} {Smed: dd_Smed_v6_854_0_8, dd_Smed_v6_854_0_8, [Score=48.1, Expect=1e-06]} {RNA1509_17775} {RNA1310_15879, RNA1509_17775} {RNA1509_17775, RNA815_12961} |
12. | MligTC455_33836 | 2065 | 43.02 | Mlig455_036757 | Neo: - Age: logFC(26M/2M)=-0.242 Region-enriched R3: 1.925/0.00000 |
CYP2J2 | 0.958 | - | - | - | - | 0.958 | - | Mlig455_036757 {REF} {Length: 1902} {Pfam: Cytochrome P450 [PF00067.24, score=314.8]} {Human: ENSG00000134716, CYP2J2, cytochrome P450 family 2 subfamily J member 2, [Score=252, Expect=2e-77]} {Mouse: ENSMUSG00000052914, Cyp2j6, cytochrome P450, family 2, subfamily j, polypeptide 6, [Score=248, Expect=4e-76]; ENSMUSG00000081225, Cyp2j12, cytochrome P450, family 2, subfamily j, polypeptide 12, [Score=248, Expect=4e-76]; ENSMUSG00000081362, Cyp2j7, cytochrome P450, family 2, subfamily j, polypeptide 7, [Score=246, Expect=3e-75]; ENSMUSG00000052520, Cyp2j5, cytochrome P450, family 2, subfamily j, polypeptide 5, [Score=246, Expect=2e-75]; ENSMUSG00000066097, Cyp2j11, cytochrome P450, family 2, subfamily j, polypeptide 11, [Score=240, Expect=7e-73]; ENSMUSG00000015224, Cyp2j9, cytochrome P450, family 2, subfamily j, polypeptide 9, [Score=239, Expect=1e-72]; ENSMUSG00000082932, Cyp2j8, cytochrome P450, family 2, subfamily j, polypeptide 8, [Score=236, Expect=2e-71]} {Dmel: FBgn0010383, Cyp18a1, Cytochrome P450-18a1, [Score=208, Expect=1e-60]} {Celegans: WBGene00016697, cyp-33C2, CYtochrome P450 family, [Score=226, Expect=7e-68]} {Smed: dd_Smed_v6_5344_0_2, dd_Smed_v6_5344_0_2, [RH, Score=260, Expect=8e-81]} {RNA1509_32471} {RNA1310_10330} {RNA815_3898.1} |
13. | MligTC455_49693 | 71 | 1.47 | Mlig455_048626 | Neo: - Age: - |
TAT | 0.955 | - | - | - | - | 0.955 | - | Mlig455_048626 {REF} {Length: 4541} {Pfam: Aminotransferase class I and II [PF00155.23, score=214.1]; Beta-eliminating lyase [PF01212.23, score=26.5]; Aminotransferase class-V [PF00266.21, score=26.4]; DegT/DnrJ/EryC1/StrS aminotransferase family [PF01041.19, score=25.4]; Cys/Met metabolism PLP-dependent enzyme [PF01053.22, score=22.2]} {Human: ENSG00000198650, TAT, tyrosine aminotransferase, [RH, Score=474, Expect=8e-165]} {Mouse: ENSMUSG00000001670, Tat, tyrosine aminotransferase, [RH, Score=483, Expect=3e-168]} {Dmel: FBgn0030558, CG1461, [RH, Score=444, Expect=1e-152]} {Celegans: WBGene00009628, tatn-1, Tyrosine AminoTraNsferase, [RH, Score=348, Expect=9e-116]} {Smed: dd_Smed_v6_1073_0_1, dd_Smed_v6_1073_0_1, [RH, Score=449, Expect=1e-155]} {RNA1509_38097} {RNA1310_4309} {RNA815_5234} |
14. | MligTC455_51816 | 845 | 17.6 | Mlig455_002795, Mlig455_002810 | Neo: - Age: - |
ZDHHC17 | 0.953 | - | - | - | 0.953 | - | - | Mlig455_002795 {REF} {Length: 2018} {Pfam: Ligand-gated ion channel [PF00060.28, score=41.4]} {RNA1509_25098} {RNA1310_16351} {RNA815_15602} Mlig455_002810 {REF} {Length: 6458} {Pfam: Ankyrin repeats (3 copies) [PF12796.9, score=139.3]; Ankyrin repeats (many copies) [PF13857.8, score=93.3]; Ankyrin repeats (many copies) [PF13637.8, score=90.4]; DHHC palmitoyltransferase [PF01529.22, score=80.3]; Ankyrin repeat [PF13606.8, score=78.1]; Ankyrin repeat [PF00023.32, score=73.0]} {Human: ENSG00000186908, ZDHHC17, zinc finger DHHC-type containing 17, [Score=160, Expect=3e-41]} {Mouse: ENSMUSG00000035798, Zdhhc17, zinc finger, DHHC domain containing 17, [Score=157, Expect=2e-40]} {Dmel: FBgn0029137, Patsas, [Score=311, Expect=4e-98]} {Celegans: WBGene00018009, dhhc-3, Palmitoyltransferase, [Score=83.2, Expect=1e-17]} {Smed: dd_Smed_v6_16314_0_1, dd_Smed_v6_16314_0_1, [Score=217, Expect=2e-63]} {RNA1509_25007, RNA1509_25098, RNA1509_45982, RNA1509_51990, RNA1509_56684} {RNA1310_9910, RNA1509_25007, RNA1509_25098, RNA1509_45982, RNA1509_51990, RNA1509_56684} {RNA1509_25007, RNA1509_25098, RNA1509_45982, RNA1509_51990, RNA1509_56684, RNA815_13589} |
15. | MligTC455_03115 | 154 | 3.22 | Mlig455_012509 | Neo: - Age: Down-Down-Down, logFC(26M/2M)=4.604 Regeneration-enriched R4: 10.061 |
VWA7 | 0.952 | - | - | - | 0.952 | - | - | Mlig455_012509 {REF} {Length: 2976} {Pfam: von Willebrand factor type A domain [PF13519.8, score=52.3]; von Willebrand factor type A domain [PF00092.30, score=28.2]; von Willebrand factor type A domain [PF13768.8, score=21.3]} {Human: ENSG00000234433, VWA7, von Willebrand factor A domain containing 7, [Score=68.9, Expect=4e-12]; ENSG00000238203, VWA7, von Willebrand factor A domain containing 7, [Score=68.9, Expect=4e-12]; ENSG00000204396, VWA7, von Willebrand factor A domain containing 7, [Score=68.9, Expect=4e-12]; ENSG00000227144, VWA7, von Willebrand factor A domain containing 7, [Score=68.9, Expect=4e-12]; ENSG00000230048, VWA7, von Willebrand factor A domain containing 7, [Score=68.9, Expect=4e-12]; ENSG00000223757, VWA7, von Willebrand factor A domain containing 7, [Score=68.9, Expect=4e-12]} {Mouse: ENSMUSG00000007030, Vwa7, von Willebrand factor A domain containing 7, [Score=67.4, Expect=8e-12]} {Celegans: WBGene00001863, him-4, Hemicentin; High Incidence of Males (Increased X chromosome loss), [Score=86.3, Expect=4e-18]} {Smed: dd_Smed_v6_1161_0_1, dd_Smed_v6_1161_0_1, [Score=73.2, Expect=6e-14]} {RNA1310_17403.1} {RNA815_6699} |
16. | MligTC455_40855 | 103 | 2.14 | Mlig455_051827 | Neo: - Age: Up-Up-Up, logFC(26M/2M)=1.299 Region-enriched R4: 4.484/0.00807 |
PANK1 | 0.952 | - | - | - | 0.952 | - | - | Mlig455_051827 {REF} {Length: 6742} {Pfam: Fumble [PF03630.16, score=90.8]} {Human: ENSG00000152782, PANK1, pantothenate kinase 1, [Score=50.8, Expect=2e-06]} {Mouse: ENSMUSG00000033610, Pank1, pantothenate kinase 1, [Score=52.0, Expect=5e-07]} {Celegans: WBGene00006862, pnk-4, PaNtothenate Kinase, [Score=58.2, Expect=5e-09]} {Smed: dd_Smed_v6_2075_0_1, dd_Smed_v6_2075_0_1, [Score=114, Expect=9e-29]} {RNA1509_43085, RNA1509_46480} {RNA1310_22321.2, RNA1509_46480} {RNA1509_46480, RNA815_8776} |
17. | MligTC455_20058 | 373 | 7.78 | Mlig455_051135 | Neo: - Age: Up-Down-Up |
AMT | 0.95 | - | - | - | 0.950 | - | - | Mlig455_051135 {REF} {Length: 1664} {TRANSSPLICED} {Pfam: Aminomethyltransferase folate-binding domain [PF01571.23, score=260.5]; Glycine cleavage T-protein C-terminal barrel domain [PF08669.13, score=63.7]} {Human: ENSG00000145020, AMT, aminomethyltransferase, [RH, Score=338, Expect=4e-113]} {Mouse: ENSMUSG00000032607, Amt, aminomethyltransferase, [RH, Score=343, Expect=3e-115]} {Dmel: FBgn0032287, CG6415, [RH, Score=310, Expect=2e-102]} {Celegans: WBGene00017765, gcst-1, Aminomethyltransferase, [RH, Score=300, Expect=1e-98]} {Smed: dd_Smed_v6_3994_0_1, dd_Smed_v6_3994_0_1, [RH, Score=346, Expect=8e-117]} {RNA1509_4904, RNA1509_54318} {RNA1310_4930.1, RNA1509_54318} {RNA1509_54318, RNA815_1503.1} |