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Results for MligTC455_46722

Cluster Total UMI counts Global CPM Transcripts Categories Human homolog Annotation
MligTC455_46722 205 4.28 Mlig455_028319

Neo: -

Age: -

CHRNA3 Mlig455_028319 {REF} {Length: 2247} {Pfam: Neurotransmitter-gated ion-channel transmembrane region [PF02932.18, score=276.5]; Neurotransmitter-gated ion-channel ligand binding domain [PF02931.25, score=220.5]} {Human: ENSG00000080644, CHRNA3, cholinergic receptor nicotinic alpha 3 subunit, [Score=421, Expect=1e-142]; ENSG00000120903, CHRNA2, cholinergic receptor nicotinic alpha 2 subunit, [Score=412, Expect=2e-138]; ENSG00000147434, CHRNA6, cholinergic receptor nicotinic alpha 6 subunit, [Score=408, Expect=2e-137]; ENSG00000117971, CHRNB4, cholinergic receptor nicotinic beta 4 subunit, [Score=403, Expect=1e-135]} {Mouse: ENSMUSG00000027950, Chrnb2, cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal), [RH, Score=407, Expect=4e-137]} {Dmel: FBgn0266347, nAChRalpha4, nicotinic Acetylcholine Receptor alpha4, [Score=504, Expect=2e-175]} {Celegans: WBGene00006797, unc-63, Acetylcholine receptor subunit alpha-type unc-63, [Score=432, Expect=5e-147]} {Smed: dd_Smed_v6_14630_0_1, dd_Smed_v6_14630_0_1, [Score=476, Expect=3e-163]} {RNA1509_55012} {RNA1310_6313.1} {RNA815_3014.1}

Cumulative graph for MligTC455_46722

Region-enriched expression

Region logFC logCPM Pvalue FDR Specificity
RegionR1 -0.26 2.768 0.91258 1.00000
RegionR2 0.267 2.768 0.73841 1.00000
RegionR3 -0.27 2.768 0.71395 1.00000
RegionR4 1.186 2.768 0.10659 0.32129
RegionR5 -0.175 2.768 0.80032 1.00000
RegionR6 -1.806 2.768 0.05575 0.44310
RegionR7 0.045 2.768 0.96186 1.00000
RegionR8 1.013 2.768 0.40180 1.00000

Regeneration-enriched expression

Region logFC logCPM PValue FDR Specificity
RegenerationR1 -5.789 2.768 0.36148 1.00000
RegenerationR2 0.497 2.768 0.37108 0.79672
RegenerationR3 0.837 2.768 0.22692 0.66203
RegenerationR4 -1.324 2.768 0.04978 0.35964
RegenerationR5 -0.775 2.768 0.24569 0.67881
RegenerationR6 0.935 2.768 0.27061 0.62098
RegenerationBL 0.002 2.768 0.99537 1.00000
RegenerationTP 0.031 2.768 0.97512 1.00000


Genes with expression patterns similar to MligTC455_46722

Nr. Cluster Total UMI counts Global CPM Transcripts Categories Human homolog Σ Spearman correlations Int1 Int2 Int3 Reg1 Reg2 Reg3 Annotation
1. MligTC455_46722 205 4.28 Mlig455_028319

Neo: -

Age: -

CHRNA3 6 1.000 1.000 1.000 1.000 1.000 1.000 Mlig455_028319 {REF} {Length: 2247} {Pfam: Neurotransmitter-gated ion-channel transmembrane region [PF02932.18, score=276.5]; Neurotransmitter-gated ion-channel ligand binding domain [PF02931.25, score=220.5]} {Human: ENSG00000080644, CHRNA3, cholinergic receptor nicotinic alpha 3 subunit, [Score=421, Expect=1e-142]; ENSG00000120903, CHRNA2, cholinergic receptor nicotinic alpha 2 subunit, [Score=412, Expect=2e-138]; ENSG00000147434, CHRNA6, cholinergic receptor nicotinic alpha 6 subunit, [Score=408, Expect=2e-137]; ENSG00000117971, CHRNB4, cholinergic receptor nicotinic beta 4 subunit, [Score=403, Expect=1e-135]} {Mouse: ENSMUSG00000027950, Chrnb2, cholinergic receptor, nicotinic, beta polypeptide 2 (neuronal), [RH, Score=407, Expect=4e-137]} {Dmel: FBgn0266347, nAChRalpha4, nicotinic Acetylcholine Receptor alpha4, [Score=504, Expect=2e-175]} {Celegans: WBGene00006797, unc-63, Acetylcholine receptor subunit alpha-type unc-63, [Score=432, Expect=5e-147]} {Smed: dd_Smed_v6_14630_0_1, dd_Smed_v6_14630_0_1, [Score=476, Expect=3e-163]} {RNA1509_55012} {RNA1310_6313.1} {RNA815_3014.1}
2. MligTC455_36372 925 19.28 Mlig455_005680

Neo: -

Age: logFC(26M/2M)=2.101

Region-enriched R2: 7.233/0.00006
Region-enriched R3: 5.803/0.00007

2.594 - - 0.719 0.962 0.913 - Mlig455_005680 {REF} {Length: 1993} {RNA1509_18409, RNA1509_31432} {RNA1310_82233, RNA1509_18409, RNA1509_31432} {RNA1509_18409, RNA1509_31432, RNA815_42934}
3. MligTC455_42911 64 1.33 Mlig455_006347, Mlig455_061245

Neo: -

Age: -

2.554 - - 0.739 0.970 0.845 -

Mlig455_006347 {REF} {Length: 1191} {RNA1310_18511} {RNA815_34926}

Mlig455_061245 {REF} {Length: 1944} {RNA1310_18511} {RNA815_34926}
4. MligTC455_42910 32 0.67 Mlig455_006397

Neo: -

Age: logFC(26M/2M)=-0.359

ANK1 2.544 - - 0.739 0.960 0.845 - Mlig455_006397 {REF} {Length: 4067} {Pfam: Ankyrin repeats (3 copies) [PF12796.9, score=209.4]; Ankyrin repeats (many copies) [PF13637.8, score=160.1]; Ankyrin repeat [PF13606.8, score=136.2]; Ankyrin repeats (many copies) [PF13857.8, score=125.6]; Ankyrin repeat [PF00023.32, score=124.1]; Mab-21 protein [PF03281.16, score=28.9]} {Human: ENSG00000029534, ANK1, ankyrin 1, [Score=186, Expect=7e-47]} {Mouse: ENSMUSG00000031543, Ank1, ankyrin 1, erythroid, [Score=179, Expect=1e-44]} {Dmel: FBgn0039590, CG10011, [Score=174, Expect=3e-43]} {Celegans: WBGene00006616, trp-4, TRP (Transient receptor potential) channel family, [Score=153, Expect=3e-37]} {Smed: dd_Smed_v6_13721_0_1, dd_Smed_v6_13721_0_1, [Score=168, Expect=6e-42]} {RNA1509_38396} {RNA1310_3944.1} {RNA815_1969}
5. MligTC455_44862 1318 27.47 Mlig455_028792

Neo: -

Age: -

Region-enriched R2: 3.389/0.00000

QPCT 2.525 - - 0.816 0.958 0.751 - Mlig455_028792 {REF} {Length: 1901} {Pfam: Peptidase family M28 [PF04389.19, score=137.7]} {Human: ENSG00000115828, QPCT, glutaminyl-peptide cyclotransferase, [RH, Score=189, Expect=5e-57]; ENSG00000011478, QPCTL, glutaminyl-peptide cyclotransferase like, [RH, Score=186, Expect=1e-55]} {Mouse: ENSMUSG00000030407, Qpctl, glutaminyl-peptide cyclotransferase-like, [RH, Score=190, Expect=3e-57]; ENSMUSG00000024084, Qpct, glutaminyl-peptide cyclotransferase (glutaminyl cyclase), [RH, Score=189, Expect=5e-57]} {Dmel: FBgn0036999, isoQC, iso Glutaminyl cyclase, [RH, Score=210, Expect=2e-65]} {Celegans: WBGene00010418, H27A22.1, [Score=182, Expect=5e-55]} {Smed: dd_Smed_v6_4861_0_2, dd_Smed_v6_4861_0_2, [Score=166, Expect=1e-48]} {RNA1509_15042, RNA1509_18145} {RNA1310_21749, RNA1509_15042, RNA1509_18145} {RNA1509_15042, RNA1509_18145, RNA815_8635.1}
6. MligTC455_36371 1892 39.41 Mlig455_005636

Neo: -

Age: Down-Down-Up

Region-enriched R2: 7.119/0.00007
Region-enriched R3: 5.785/0.00006

C6orf120 2.506 - - 0.721 0.952 0.833 - Mlig455_005636 {REF} {Length: 4589} {TRANSSPLICED} {Pfam: Putative cytokine, C6ORF120 [PF17065.7, score=46.3]} {Human: ENSG00000185127, C6orf120, chromosome 6 open reading frame 120, [Score=52.8, Expect=5e-08]} {Mouse: ENSMUSG00000050088, 1600012H06Rik, RIKEN cDNA 1600012H06 gene, [Score=52.4, Expect=5e-08]} {RNA1509_33302, RNA1509_46654} {RNA1310_15958, RNA1509_46654} {RNA1509_46654, RNA815_10779}
7. MligTC455_49296 69 1.44 Mlig455_034352, Mlig455_034414

Neo: -

Age: -

2.445 - - 0.730 0.953 0.762 -

Mlig455_034352 {REF} {Length: 912} {TRANSSPLICED}

Mlig455_034414 {REF} {Length: 919} {TRANSSPLICED}
8. MligTC455_48603 1006 20.95 Mlig455_058556

Neo: -

Age: -

Region-enriched R2: 1.380/0.01205

Regeneration-downregulated BL: -2.368

Regeneration-depleted BL: -2.368

CALM2 2.44 - - - 0.954 0.741 0.745 Mlig455_058556 {REF} {Length: 2727} {TRANSSPLICED} {Pfam: EF-hand domain pair [PF13499.8, score=101.0]; EF hand [PF00036.34, score=97.2]; EF-hand domain pair [PF13833.8, score=81.7]; EF-hand domain [PF13405.8, score=78.5]; EF hand [PF13202.8, score=71.6]; EF-hand domain [PF14658.8, score=41.8]; Secreted protein acidic and rich in cysteine Ca binding region [PF10591.11, score=31.1]; Cytoskeletal-regulatory complex EF hand [PF12763.9, score=27.3]; Dockerin type I domain [PF00404.20, score=25.5]; SurA N-terminal domain [PF13624.8, score=19.1]} {Human: ENSG00000143933, CALM2, calmodulin 2, [Score=132, Expect=1e-37]; ENSG00000160014, CALM3, calmodulin 3, [Score=130, Expect=5e-37]; ENSG00000198668, CALM1, calmodulin 1, [Score=130, Expect=3e-37]} {Mouse: ENSMUSG00000001175, Calm1, calmodulin 1, [Score=135, Expect=8e-39]; ENSMUSG00000036438, Calm2, calmodulin 2, [Score=130, Expect=3e-37]; ENSMUSG00000019370, Calm3, calmodulin 3, [Score=130, Expect=3e-37]} {Dmel: FBgn0000253, Cam, Calmodulin, [Score=127, Expect=3e-36]} {Celegans: WBGene00000552, cmd-1, Calmodulin, [Score=127, Expect=2e-36]} {Smed: dd_Smed_v6_12048_0_2, dd_Smed_v6_12048_0_2, [RH, Score=163, Expect=8e-49]} {RNA1509_36324, RNA1509_52694, RNA1509_5720} {RNA1310_6210.2, RNA1509_36324, RNA1509_52694, RNA1509_5720} {RNA1509_36324, RNA1509_52694, RNA1509_5720, RNA815_4293.1}
9. MligTC455_42601 438 9.12 Mlig455_019930

Neo: -

Age: -

Region-enriched R7: 1.726/0.03073

1.863 - - - 0.957 0.906 - Mlig455_019930 {REF} {Length: 618} {TRANSSPLICED} {Pfam: PLAC8 family [PF04749.19, score=78.5]} {Smed: dd_Smed_v6_477_0_1, dd_Smed_v6_477_0_1, [RH, Score=129, Expect=2e-40]} {RNA1509_14839} {RNA1310_21645} {RNA815_8854.1}
10. MligTC455_34233 101 2.11 Mlig455_053145

Neo: -

Age: Down-Up-Down

ACR 1.84 - - - 0.960 0.880 - Mlig455_053145 {REF} {Length: 1245} {Pfam: Trypsin [PF00089.28, score=175.3]} {Human: ENSG00000100312, ACR, acrosin, [Score=161, Expect=1e-45]; ENSG00000283539, ACR, acrosin, [Score=161, Expect=1e-45]; ENSG00000122194, PLG, plasminogen, [Score=156, Expect=8e-42]; ENSG00000198670, LPA, lipoprotein(a), [Score=155, Expect=2e-41]; ENSG00000178297, TMPRSS9, transmembrane serine protease 9, [Score=154, Expect=3e-41]} {Mouse: ENSMUSG00000059481, Plg, plasminogen, [Score=152, Expect=1e-40]; ENSMUSG00000059406, Tmprss9, transmembrane protease, serine 9, [Score=151, Expect=4e-40]; ENSMUSG00000016942, Tmprss6, transmembrane serine protease 6, [Score=149, Expect=1e-39]; ENSMUSG00000033177, Tmprss7, transmembrane serine protease 7, [Score=145, Expect=4e-38]} {Dmel: FBgn0036287, CG10663, [Score=132, Expect=6e-34]} {Celegans: WBGene00006619, try-1, TRYpsin-like protease, [Score=125, Expect=2e-33]} {Smed: dd_Smed_v6_2492_0_1, dd_Smed_v6_2492_0_1, [Score=175, Expect=3e-52]} {RNA1509_37786} {RNA1310_26421} {RNA815_13601}
11. MligTC455_46285 568 11.84 Mlig455_063390

Neo: -

Age: logFC(26M/2M)=0.488

Region-enriched R2: 4.933/0.00026
Region-enriched R3: 3.321/0.00307

1.817 - - - 0.854 0.963 - Mlig455_063390 {REF} {Length: 871} {RNA1509_48573} {RNA1310_59611, RNA1509_48573} {RNA1509_48573, RNA815_35731}
12. MligTC455_51127 32 0.66 Mlig455_054349

Neo: -

Age: -

GLRA2 1.81 - - - 0.975 0.835 - Mlig455_054349 {REF} {Length: 2070} {Pfam: Neurotransmitter-gated ion-channel ligand binding domain [PF02931.25, score=154.6]; Neurotransmitter-gated ion-channel transmembrane region [PF02932.18, score=108.3]} {Human: ENSG00000101958, GLRA2, glycine receptor alpha 2, [Score=317, Expect=6e-102]; ENSG00000145451, GLRA3, glycine receptor alpha 3, [Score=316, Expect=1e-101]; ENSG00000145888, GLRA1, glycine receptor alpha 1, [Score=312, Expect=3e-100]} {Mouse: ENSMUSG00000018589, Glra2, glycine receptor, alpha 2 subunit, [Score=317, Expect=3e-102]; ENSMUSG00000038257, Glra3, glycine receptor, alpha 3 subunit, [Score=316, Expect=1e-101]; ENSMUSG00000018595, Glra4, glycine receptor, alpha 4 subunit, [Score=308, Expect=1e-98]} {Dmel: FBgn0024963, GluClalpha, [Score=288, Expect=3e-91]} {Celegans: WBGene00020767, lgc-40, Ligand-Gated ion Channel, [RH, Score=260, Expect=4e-80]} {Smed: dd_Smed_v6_10794_0_1, dd_Smed_v6_10794_0_1, [Score=261, Expect=1e-80]} {RNA1310_34255} {RNA815_61641}
13. MligTC455_37682 225 4.68 Mlig455_022978, Mlig455_023072

Neo: -

Age: Up-Down-Up

Region-enriched R7: 2.657/0.03586

KCNN2 1.801 - - - 0.959 0.842 -

Mlig455_022978 {REF} {Length: 4236} {Pfam: Calcium-activated SK potassium channel [PF03530.16, score=149.3]; Calmodulin binding domain [PF02888.18, score=116.8]; Ion channel [PF07885.18, score=49.6]} {Human: ENSG00000080709, KCNN2, potassium calcium-activated channel subfamily N member 2, [RH, Score=548, Expect=0.0]; ENSG00000143603, KCNN3, potassium calcium-activated channel subfamily N member 3, [RH, Score=539, Expect=1e-180]} {Mouse: ENSMUSG00000054477, Kcnn2, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2, [RH, Score=549, Expect=0.0]; ENSMUSG00000000794, Kcnn3, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3, [RH, Score=541, Expect=0.0]} {Dmel: FBgn0029761, SK, small conductance calcium-activated potassium channel, [RH, Score=637, Expect=0.0]} {Celegans: WBGene00008570, kcnl-2, KCNL-2 variant; KCNN (Potassium K ChaNNel, calcium activated)-Like, [RH, Score=424, Expect=5e-135]} {Smed: dd_Smed_v6_15620_0_1, dd_Smed_v6_15620_0_1, [RH, Score=572, Expect=0.0]} {RNA1509_28013} {RNA1310_5308.1, RNA1509_28013} {RNA1509_28013, RNA815_7768}

Mlig455_023072 {REF} {Length: 3426} {Pfam: Calcium-activated SK potassium channel [PF03530.16, score=149.3]; Calmodulin binding domain [PF02888.18, score=116.0]; Ion channel [PF07885.18, score=49.6]} {Human: ENSG00000080709, KCNN2, potassium calcium-activated channel subfamily N member 2, [RH, Score=534, Expect=3e-177]; ENSG00000143603, KCNN3, potassium calcium-activated channel subfamily N member 3, [RH, Score=525, Expect=2e-175]} {Mouse: ENSMUSG00000054477, Kcnn2, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 2, [RH, Score=536, Expect=1e-178]; ENSMUSG00000000794, Kcnn3, potassium intermediate/small conductance calcium-activated channel, subfamily N, member 3, [RH, Score=528, Expect=1e-176]} {Dmel: FBgn0029761, SK, small conductance calcium-activated potassium channel, [RH, Score=627, Expect=0.0]} {Celegans: WBGene00008570, kcnl-2, KCNL-2 variant; KCNN (Potassium K ChaNNel, calcium activated)-Like, [RH, Score=410, Expect=8e-130]} {Smed: dd_Smed_v6_15620_0_1, dd_Smed_v6_15620_0_1, [RH, Score=559, Expect=0.0]} {RNA1509_28013} {RNA1310_5308.1} {RNA815_7768}
14. MligTC455_47393 241 5.03 Mlig455_008718, Mlig455_063579

Neo: -

Age: Down-Up-Down

Region-enriched R2: 3.683/0.00849

CALM2 1.8 - - - 0.951 0.849 -

Mlig455_008718 {REF} {Length: 1727} {Pfam: EF hand [PF00036.34, score=99.3]; EF-hand domain pair [PF13499.8, score=95.1]; EF-hand domain [PF13405.8, score=86.1]; EF-hand domain pair [PF13833.8, score=76.8]; EF hand [PF13202.8, score=75.3]; EF-hand domain [PF14658.8, score=46.0]; Secreted protein acidic and rich in cysteine Ca binding region [PF10591.11, score=38.5]; Cytoskeletal-regulatory complex EF hand [PF12763.9, score=27.9]; EF-hand domain [PF08976.13, score=23.4]; Uncharacterised protein family (UPF0154) [PF03672.15, score=18.7]} {Human: ENSG00000143933, CALM2, calmodulin 2, [Score=108, Expect=4e-30]; ENSG00000160014, CALM3, calmodulin 3, [Score=108, Expect=4e-30]; ENSG00000198668, CALM1, calmodulin 1, [Score=108, Expect=4e-30]} {Mouse: ENSMUSG00000019370, Calm3, calmodulin 3, [Score=108, Expect=2e-30]; ENSMUSG00000036438, Calm2, calmodulin 2, [Score=108, Expect=2e-30]; ENSMUSG00000001175, Calm1, calmodulin 1, [Score=108, Expect=2e-30]; ENSMUSG00000063130, Calml3, calmodulin-like 3, [Score=106, Expect=1e-29]} {Dmel: FBgn0000253, Cam, Calmodulin, [Score=107, Expect=3e-30]} {Celegans: WBGene00000552, cmd-1, Calmodulin, [Score=107, Expect=2e-30]} {Smed: dd_Smed_v6_3441_0_1, dd_Smed_v6_3441_0_1, [Score=114, Expect=8e-33]} {RNA1310_33847.1} {RNA815_17211}

Mlig455_063579 {REF} {Length: 2562} {Pfam: EF hand [PF00036.34, score=95.8]; EF-hand domain pair [PF13499.8, score=92.8]; EF-hand domain [PF13405.8, score=82.9]; EF-hand domain pair [PF13833.8, score=74.4]; EF hand [PF13202.8, score=72.2]; EF-hand domain [PF14658.8, score=43.8]; Secreted protein acidic and rich in cysteine Ca binding region [PF10591.11, score=38.5]; Cytoskeletal-regulatory complex EF hand [PF12763.9, score=25.6]; EF-hand domain [PF08976.13, score=21.4]} {Human: ENSG00000143933, CALM2, calmodulin 2, [Score=111, Expect=7e-30]; ENSG00000198668, CALM1, calmodulin 1, [Score=108, Expect=3e-29]; ENSG00000160014, CALM3, calmodulin 3, [Score=108, Expect=3e-29]} {Mouse: ENSMUSG00000001175, Calm1, calmodulin 1, [Score=111, Expect=7e-30]; ENSMUSG00000036438, Calm2, calmodulin 2, [Score=108, Expect=2e-29]; ENSMUSG00000019370, Calm3, calmodulin 3, [Score=108, Expect=2e-29]; ENSMUSG00000063130, Calml3, calmodulin-like 3, [Score=106, Expect=9e-29]} {Dmel: FBgn0000253, Cam, Calmodulin, [Score=107, Expect=3e-29]} {Celegans: WBGene00000552, cmd-1, Calmodulin, [Score=107, Expect=2e-29]} {Smed: dd_Smed_v6_3441_0_1, dd_Smed_v6_3441_0_1, [Score=111, Expect=9e-31]} {RNA1310_12431.1} {RNA815_17211}
15. MligTC455_23143 413 8.6 Mlig455_008087

Neo: -

Age: -

Region-enriched R2: 2.201/0.04155

INSR 1.784 - - 0.831 0.953 - - Mlig455_008087 {REF} {Length: 5415} {TRANSSPLICED} {Pfam: Protein tyrosine and serine/threonine kinase [PF07714.19, score=291.7]; Protein kinase domain [PF00069.27, score=128.3]; Receptor L domain [PF01030.26, score=118.3]; Furin-like cysteine rich region [PF00757.22, score=79.0]; Fibronectin type III domain [PF00041.23, score=43.3]; Growth factor receptor domain IV [PF14843.8, score=19.7]} {Human: ENSG00000171105, INSR, insulin receptor, [RH, Score=647, Expect=0.0]} {Mouse: ENSMUSG00000005534, Insr, insulin receptor, [RH, Score=643, Expect=0.0]} {Dmel: FBgn0283499, InR, Insulin-like receptor, [RH, Score=333, Expect=9e-93]} {Celegans: WBGene00000898, daf-2, Insulin-like receptor Insulin-like receptor subunit alpha Insulin-like receptor subunit beta, [RH, Score=477, Expect=6e-141]} {Smed: dd_Smed_v6_9006_0_1, dd_Smed_v6_9006_0_1, [RH, Score=516, Expect=7e-158]} {RNA1509_32205, RNA1509_5152} {RNA1310_762.1, RNA1509_32205, RNA1509_5152} {RNA1509_32205, RNA1509_5152, RNA815_285.1}
16. MligTC455_48520 46 0.96 Mlig455_004433

Neo: -

Age: -

1.782 - - 0.799 0.983 - - Mlig455_004433 {REF} {Length: 701} {RNA1310_56623} {RNA815_27009}
17. MligTC455_31696 99 2.06 Mlig455_054925

Neo: -

Age: Down-Down-Up

1.775 - - - 0.820 0.955 - Mlig455_054925 {REF} {Length: 1987} {RNA1310_24838} {RNA815_18727}
18. MligTC455_33257 441 9.18 Mlig455_032762

Neo: -

Age: Down-Up-Up, logFC(26M/2M)=0.898

Region-enriched R7: 7.302/0.00324

ADAMTS1 1.754 - - 0.798 - 0.956 - Mlig455_032762 {REF} {Length: 2204} {Pfam: Metallo-peptidase family M12 [PF13688.8, score=49.6]; Metallo-peptidase family M12B Reprolysin-like [PF13582.8, score=41.2]; Reprolysin (M12B) family zinc metalloprotease [PF01421.21, score=41.1]; Metallo-peptidase family M12B Reprolysin-like [PF13574.8, score=35.5]; Metallo-peptidase family M12B Reprolysin-like [PF13583.8, score=29.0]; ADAM cysteine-rich domain [PF17771.3, score=25.4]} {Human: ENSG00000154734, ADAMTS1, ADAM metallopeptidase with thrombospondin type 1 motif 1, [Score=74.7, Expect=3e-13]; ENSG00000145808, ADAMTS19, ADAM metallopeptidase with thrombospondin type 1 motif 19, [Score=74.3, Expect=5e-13]} {Mouse: ENSMUSG00000006403, Adamts4, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 4, [Score=70.5, Expect=5e-12]; ENSMUSG00000022893, Adamts1, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 1, [Score=68.9, Expect=2e-11]; ENSMUSG00000031994, Adamts8, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 8, [Score=68.6, Expect=2e-11]; ENSMUSG00000053441, Adamts19, a disintegrin-like and metallopeptidase (reprolysin type) with thrombospondin type 1 motif, 19, [Score=68.6, Expect=2e-11]} {Dmel: FBgn0034903, sona, sol narae, [Score=73.2, Expect=5e-13]} {Celegans: WBGene00003248, mig-17, ADAM family mig-17, [Score=57.0, Expect=3e-08]} {RNA1509_380} {RNA1310_14719} {RNA815_5216}
19. MligTC455_44339 100 2.08 Mlig455_001551

Neo: -

Age: -

GPR158 1.747 - - 0.781 0.966 - - Mlig455_001551 {REF} {Length: 3428} {Pfam: 7 transmembrane sweet-taste receptor of 3 GCPR [PF00003.24, score=94.6]} {Human: ENSG00000151025, GPR158, G protein-coupled receptor 158, [RH, Score=246, Expect=6e-68]; ENSG00000276469, GPR179, G protein-coupled receptor 179, [RH, Score=240, Expect=2e-65]; ENSG00000277399, GPR179, G protein-coupled receptor 179, [RH, Score=234, Expect=2e-63]} {Mouse: ENSMUSG00000070337, Gpr179, G protein-coupled receptor 179, [RH, Score=253, Expect=6e-70]; ENSMUSG00000045967, Gpr158, G protein-coupled receptor 158, [RH, Score=251, Expect=8e-70]} {Dmel: FBgn0051660, smog, [RH, Score=293, Expect=1e-85]} {Celegans: WBGene00009558, F39B2.8, [Score=194, Expect=8e-53]} {Smed: dd_Smed_v6_8408_0_1, dd_Smed_v6_8408_0_1, [RH, Score=359, Expect=1e-112]} {RNA1509_37699} {RNA1310_6430} {RNA815_19661}
20. MligTC455_47949 48 1 Mlig455_026482, Mlig455_026492

Neo: -

Age: -

CHRNA3 1.746 - - 0.786 0.960 - -

Mlig455_026482 {REF} {Length: 2240} {Pfam: Neurotransmitter-gated ion-channel transmembrane region [PF02932.18, score=248.1]; Neurotransmitter-gated ion-channel ligand binding domain [PF02931.25, score=225.1]} {Human: ENSG00000080644, CHRNA3, cholinergic receptor nicotinic alpha 3 subunit, [Score=398, Expect=8e-133]; ENSG00000147434, CHRNA6, cholinergic receptor nicotinic alpha 6 subunit, [Score=382, Expect=5e-127]; ENSG00000120903, CHRNA2, cholinergic receptor nicotinic alpha 2 subunit, [Score=382, Expect=2e-126]} {Mouse: ENSMUSG00000032303, Chrna3, cholinergic receptor, nicotinic, alpha polypeptide 3, [Score=398, Expect=4e-133]; ENSMUSG00000031491, Chrna6, cholinergic receptor, nicotinic, alpha polypeptide 6, [Score=397, Expect=5e-133]; ENSMUSG00000022041, Chrna2, cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal), [Score=384, Expect=1e-127]} {Dmel: FBgn0000036, nAChRalpha1, nicotinic Acetylcholine Receptor alpha1, [Score=473, Expect=1e-161]} {Celegans: WBGene00006797, unc-63, Acetylcholine receptor subunit alpha-type unc-63, [Score=445, Expect=7e-152]} {Smed: dd_Smed_v6_9799_0_1, dd_Smed_v6_9799_0_1, [Score=416, Expect=2e-140]} {RNA1310_45284} {RNA815_36657}

Mlig455_026492 {REF} {Length: 1090} {Pfam: Neurotransmitter-gated ion-channel transmembrane region [PF02932.18, score=248.1]; Neurotransmitter-gated ion-channel ligand binding domain [PF02931.25, score=225.1]} {Human: ENSG00000080644, CHRNA3, cholinergic receptor nicotinic alpha 3 subunit, [Score=398, Expect=8e-133]; ENSG00000147434, CHRNA6, cholinergic receptor nicotinic alpha 6 subunit, [Score=382, Expect=5e-127]; ENSG00000120903, CHRNA2, cholinergic receptor nicotinic alpha 2 subunit, [Score=382, Expect=2e-126]} {Mouse: ENSMUSG00000032303, Chrna3, cholinergic receptor, nicotinic, alpha polypeptide 3, [Score=398, Expect=4e-133]; ENSMUSG00000031491, Chrna6, cholinergic receptor, nicotinic, alpha polypeptide 6, [Score=397, Expect=5e-133]; ENSMUSG00000022041, Chrna2, cholinergic receptor, nicotinic, alpha polypeptide 2 (neuronal), [Score=384, Expect=1e-127]} {Dmel: FBgn0000036, nAChRalpha1, nicotinic Acetylcholine Receptor alpha1, [Score=473, Expect=1e-161]} {Celegans: WBGene00006797, unc-63, Acetylcholine receptor subunit alpha-type unc-63, [Score=445, Expect=7e-152]} {Smed: dd_Smed_v6_9799_0_1, dd_Smed_v6_9799_0_1, [Score=416, Expect=2e-140]} {RNA1310_45284} {RNA815_36657}
21. MligTC455_47911 454 9.45 Mlig455_025174, Mlig455_025185, Mlig455_063945

Neo: -

Age: Down-Down-Up

Region-enriched R7: 1.848/0.00637

INAFM2 1.697 - - - - 0.956 0.741

Mlig455_025174 {REF} {Length: 1166} {Pfam: TRP-interacting helix [PF15018.8, score=59.1]; Voltage-dependent anion channel [PF03595.19, score=21.3]} {Human: ENSG00000259330, INAFM2, InaF motif containing 2, [RH, Score=72.4, Expect=4e-17]} {Mouse: ENSMUSG00000074918, Inafm2, InaF motif containing 2, [RH, Score=72.0, Expect=4e-17]} {Dmel: FBgn0260812, inaF-D, [RH, Score=51.6, Expect=6e-09]} {Celegans: WBGene00009325, F32D8.15, [RH, Score=48.5, Expect=2e-08]} {Smed: dd_Smed_v6_11468_0_1, dd_Smed_v6_11468_0_1, [RH, Score=66.6, Expect=6e-16]} {RNA1509_26679} {RNA1310_3928} {RNA815_30540}

Mlig455_025185 {REF} {Length: 1331} {Pfam: TRP-interacting helix [PF15018.8, score=59.1]; Voltage-dependent anion channel [PF03595.19, score=21.3]} {Human: ENSG00000259330, INAFM2, InaF motif containing 2, [RH, Score=72.4, Expect=4e-17]} {Mouse: ENSMUSG00000074918, Inafm2, InaF motif containing 2, [RH, Score=72.0, Expect=4e-17]} {Dmel: FBgn0260812, inaF-D, [RH, Score=51.6, Expect=6e-09]} {Celegans: WBGene00009325, F32D8.15, [RH, Score=48.5, Expect=2e-08]} {Smed: dd_Smed_v6_11468_0_1, dd_Smed_v6_11468_0_1, [RH, Score=66.6, Expect=6e-16]} {RNA1509_26679} {RNA1310_3928, RNA1509_26679} {RNA1509_26679, RNA815_30540}

Mlig455_063945 {REF} {Length: 1146} {Pfam: TRP-interacting helix [PF15018.8, score=59.1]; Voltage-dependent anion channel [PF03595.19, score=21.3]} {Human: ENSG00000259330, INAFM2, InaF motif containing 2, [RH, Score=72.4, Expect=4e-17]} {Mouse: ENSMUSG00000074918, Inafm2, InaF motif containing 2, [RH, Score=72.0, Expect=4e-17]} {Dmel: FBgn0260812, inaF-D, [RH, Score=51.6, Expect=6e-09]} {Celegans: WBGene00009325, F32D8.15, [RH, Score=48.5, Expect=2e-08]} {Smed: dd_Smed_v6_11468_0_1, dd_Smed_v6_11468_0_1, [RH, Score=66.6, Expect=6e-16]} {RNA1509_26679, RNA1509_58648} {RNA1310_3928, RNA1509_58648} {RNA1509_58648, RNA815_30540}
22. MligTC455_19809 798 16.63 Mlig455_060372

Neo: -

Age: Up-Down-Down, logFC(26M/2M)=-0.288

Region-enriched R2: 1.440/0.00492

CACNA1C 1.694 - - 0.740 0.954 - - Mlig455_060372 {REF} {Length: 8744} {Pfam: Ion transport protein [PF00520.33, score=796.8]; Voltage-dependent L-type calcium channel, IQ-associated [PF16905.7, score=96.5]; Voltage gated calcium channel IQ domain [PF08763.13, score=95.7]; Polycystin cation channel [PF08016.14, score=39.1]} {Human: ENSG00000151067, CACNA1C, calcium voltage-gated channel subunit alpha1 C, [Score=1289, Expect=0.0]; ENSG00000285479, CACNA1C, calcium voltage-gated channel subunit alpha1 C, [Score=1289, Expect=0.0]; ENSG00000081248, CACNA1S, calcium voltage-gated channel subunit alpha1 S, [Score=1281, Expect=0.0]; ENSG00000102001, CACNA1F, calcium voltage-gated channel subunit alpha1 F, [Score=1260, Expect=0.0]; ENSG00000157388, CACNA1D, calcium voltage-gated channel subunit alpha1 D, [Score=1254, Expect=0.0]} {Mouse: ENSMUSG00000051331, Cacna1c, calcium channel, voltage-dependent, L type, alpha 1C subunit, [Score=1304, Expect=0.0]; ENSMUSG00000026407, Cacna1s, calcium channel, voltage-dependent, L type, alpha 1S subunit, [Score=1273, Expect=0.0]; ENSMUSG00000031142, Cacna1f, calcium channel, voltage-dependent, alpha 1F subunit, [Score=1270, Expect=0.0]; ENSMUSG00000015968, Cacna1d, calcium channel, voltage-dependent, L type, alpha 1D subunit, [Score=1259, Expect=0.0]} {Dmel: FBgn0263111, cac, cacophony, [RH, Score=1845, Expect=0.0]} {Celegans: WBGene00006742, unc-2, High voltage activated calcium channel alpha-1 subunit, [RH, Score=1742, Expect=0.0]} {Smed: dd_Smed_v6_13295_0_1, dd_Smed_v6_13295_0_1, [RH, Score=2169, Expect=0.0]} {RNA1509_13061} {RNA1310_6260.1} {RNA815_730.1}
23. MligTC455_53251 67 1.4 Mlig455_018510

Neo: -

Age: logFC(26M/2M)=0.877

Region-enriched R2: 4.210/0.03685

SYT7 1.686 - - - 0.963 0.723 - Mlig455_018510 {REF} {Length: 3473} {Pfam: C2 domain [PF00168.32, score=157.9]} {Human: ENSG00000011347, SYT7, synaptotagmin 7, [RH, Score=261, Expect=1e-79]} {Mouse: ENSMUSG00000024743, Syt7, synaptotagmin VII, [RH, Score=251, Expect=2e-77]} {Dmel: FBgn0039900, Syt7, Synaptotagmin 7, [Score=233, Expect=6e-74]} {Celegans: WBGene00004923, snt-3, SyNapTotagmin, [Score=179, Expect=4e-53]} {Smed: dd_Smed_v6_4222_0_1, dd_Smed_v6_4222_0_1, [Score=194, Expect=1e-57]} {RNA1509_49257} {RNA1310_13701} {RNA815_8339}
24. MligTC455_09221 30 0.62 Mlig455_017881

Neo: -

Age: -

0.975 - - - 0.975 - - Mlig455_017881 {REF} {Length: 792} {NoTransDecoderORF} {RNA1310_97207} {RNA815_52780}
25. MligTC455_36134 629 13.1 Mlig455_020317

Neo: -

Age: Up-Down-Down, logFC(26M/2M)=-0.348

Region-enriched R6: 1.633/0.04185

TBC1D2B 0.97 - - - 0.970 - - Mlig455_020317 {REF} {Length: 6353} {Pfam: Rab-GTPase-TBC domain [PF00566.20, score=173.2]; WD40 repeated domain [PF19056.2, score=69.4]; PH domain [PF00169.31, score=46.5]} {Human: ENSG00000167202, TBC1D2B, TBC1 domain family member 2B, [RH, Score=240, Expect=2e-64]} {Mouse: ENSMUSG00000037410, Tbc1d2b, TBC1 domain family, member 2B, [RH, Score=248, Expect=4e-67]} {Dmel: FBgn0038304, CG12241, [RH, Score=164, Expect=4e-41]} {Celegans: WBGene00007849, tbc-19, TBC (Tre-2/Bub2/Cdc16) domain family, [RH, Score=448, Expect=3e-133]} {Smed: dd_Smed_v6_2925_0_1, dd_Smed_v6_2925_0_1, [RH, Score=173, Expect=5e-44]} {RNA1509_10466, RNA1509_57985} {RNA1310_600, RNA1509_57985} {RNA1509_57985, RNA815_147.1}
26. MligTC455_54016 22 0.46 Mlig455_052032

Neo: -

Age: -

0.97 - - - 0.970 - - Mlig455_052032 {REF} {Length: 2164} {RNA1509_56320} {RNA1310_36677} {RNA815_44241}
27. MligTC455_15765 194 4.05 Mlig455_007606

Neo: -

Age: -

0.969 - - - 0.969 - - Mlig455_007606 {REF} {Length: 1349} {RNA1310_25770.1} {RNA815_11095}
28. MligTC455_25252 56 1.17 Mlig455_041099

Neo: -

Age: Down-Up-Down, logFC(26M/2M)=-0.304

0.962 - - - 0.962 - - Mlig455_041099 {REF} {Length: 4133} {Pfam: Protein of unknown function (DUF1722) [PF08349.13, score=20.9]} {RNA1509_30687} {RNA1310_3877.1, RNA1509_30687} {RNA1509_30687, RNA815_1645}
29. MligTC455_39263 254 5.29 Mlig455_047907, Mlig455_047995

Neo: -

Age: Up-Down-Down

NALCN 0.961 - - - 0.961 - -

Mlig455_047907 {REF} {Length: 7344} {TRANSSPLICED} {Pfam: Ion transport protein [PF00520.33, score=414.2]} {Human: ENSG00000102452, NALCN, sodium leak channel, non-selective, [RH, Score=1566, Expect=0.0]} {Mouse: ENSMUSG00000000197, Nalcn, sodium leak channel, non-selective, [RH, Score=1570, Expect=0.0]} {Dmel: FBgn0002917, na, narrow abdomen, [RH, Score=1579, Expect=0.0]} {Celegans: WBGene00003558, nca-2, Four domain-type voltage-gated ion channel alpha-1 subunit; Novel Channel type/putative Nematode CAlcium channel, [RH, Score=1343, Expect=0.0]} {Smed: dd_Smed_v6_7314_0_1, dd_Smed_v6_7314_0_1, [RH, Score=1756, Expect=0.0]} {RNA1509_7723} {RNA1310_7866.2, RNA1509_7723} {RNA1509_7723, RNA815_2697}

Mlig455_047995 {REF} {Length: 7874} {TRANSSPLICED} {Pfam: Ion transport protein [PF00520.33, score=413.4]} {Human: ENSG00000102452, NALCN, sodium leak channel, non-selective, [RH, Score=1565, Expect=0.0]} {Mouse: ENSMUSG00000000197, Nalcn, sodium leak channel, non-selective, [RH, Score=1568, Expect=0.0]} {Dmel: FBgn0002917, na, narrow abdomen, [RH, Score=1580, Expect=0.0]} {Celegans: WBGene00003558, nca-2, Four domain-type voltage-gated ion channel alpha-1 subunit; Novel Channel type/putative Nematode CAlcium channel, [RH, Score=1345, Expect=0.0]} {Smed: dd_Smed_v6_7314_0_1, dd_Smed_v6_7314_0_1, [RH, Score=1756, Expect=0.0]} {RNA1509_38963, RNA1509_44333, RNA1509_7723} {RNA1310_7866.2, RNA1509_38963, RNA1509_44333} {RNA1509_38963, RNA1509_44333, RNA815_2697}
30. MligTC455_46761 1116 23.26 Mlig455_063765

Neo: -

Age: logFC(26M/2M)=0.304

SLC1A2 0.961 - - - - 0.961 - Mlig455_063765 {REF} {Length: 3371} {Pfam: Sodium:dicarboxylate symporter family [PF00375.20, score=425.5]} {Human: ENSG00000110436, SLC1A2, solute carrier family 1 member 2, [RH, Score=534, Expect=0.0]} {Mouse: ENSMUSG00000005089, Slc1a2, solute carrier family 1 (glial high affinity glutamate transporter), member 2, [RH, Score=545, Expect=0.0]} {Dmel: FBgn0026439, Eaat1, Excitatory amino acid transporter 1, [RH, Score=382, Expect=5e-127]} {Celegans: WBGene00001620, glt-1, Excitatory amino acid transporter, [RH, Score=532, Expect=0.0]} {Smed: dd_Smed_v6_7570_0_1, dd_Smed_v6_7570_0_1, [RH, Score=607, Expect=0.0]} {RNA1509_2356} {RNA1310_5021.1} {RNA815_1444.1}
31. MligTC455_23544 169 3.53 Mlig455_021925

Neo: -

Age: Up-Down-Down

Region-enriched R2: 3.394/0.00033

DDR2 0.957 - - - 0.957 - - Mlig455_021925 {REF} {Length: 4813} {Pfam: Protein tyrosine and serine/threonine kinase [PF07714.19, score=205.5]; Protein kinase domain [PF00069.27, score=103.7]; F5/8 type C domain [PF00754.27, score=57.5]} {Human: ENSG00000162733, DDR2, discoidin domain receptor tyrosine kinase 2, [Score=249, Expect=1e-68]} {Mouse: ENSMUSG00000026674, Ddr2, discoidin domain receptor family, member 2, [Score=251, Expect=1e-69]} {Dmel: FBgn0053531, Ddr, Discoidin domain receptor, [Score=238, Expect=3e-64]} {Celegans: WBGene00017381, svh-4, Discoidin domain-containing receptor tyrosine kinase B, [Score=176, Expect=3e-45]} {Smed: dd_Smed_v6_22332_0_1, dd_Smed_v6_22332_0_1, [Score=187, Expect=2e-48]} {RNA1509_46581} {RNA1310_21361} {RNA815_21661}
32. MligTC455_40270 49 1.03 Mlig455_002977

Neo: -

Age: Down-Up-Down

Region-enriched R2: 7.640/0.00158

AGAP1 0.955 - - - 0.955 - - Mlig455_002977 {REF} {Length: 2591} {Pfam: Ras family [PF00071.24, score=40.1]; Unstructured region C-term to UIM in Ataxin3 [PF16619.7, score=21.9]} {Human: ENSG00000157985, AGAP1, ArfGAP with GTPase domain, ankyrin repeat and PH domain 1, [Score=253, Expect=3e-81]; ENSG00000133612, AGAP3, ArfGAP with GTPase domain, ankyrin repeat and PH domain 3, [Score=243, Expect=2e-77]} {Mouse: ENSMUSG00000055013, Agap1, ArfGAP with GTPase domain, ankyrin repeat and PH domain 1, [Score=253, Expect=2e-77]; ENSMUSG00000023353, Agap3, ArfGAP with GTPase domain, ankyrin repeat and PH domain 3, [Score=243, Expect=2e-77]} {Dmel: FBgn0028509, CenG1A, Centaurin gamma 1A, [Score=251, Expect=7e-76]} {Celegans: WBGene00000566, cnt-2, Arf-GAP with ANK repeat and PH domain-containing protein cnt-2, [Score=205, Expect=2e-59]} {Smed: dd_Smed_v6_4301_0_1, dd_Smed_v6_4301_0_1, [Score=232, Expect=7e-73]} {RNA1509_22773} {RNA1310_2370} {RNA815_11138}
33. MligTC455_34240 98 2.04 Mlig455_067901

Neo: -

Age: logFC(26M/2M)=-0.482

0.954 - - - - - 0.954 Mlig455_067901 {REF} {Length: 2932} {RNA1310_22409} {RNA815_36119}
34. MligTC455_41571 277 5.77 Mlig455_024103

Neo: -

Age: -

Region-enriched R2: 6.275/0.00003

SULT1C3 0.954 - - - - 0.954 - Mlig455_024103 {REF} {Length: 1438} {TRANSSPLICED} {Pfam: Sulfotransferase domain [PF00685.29, score=136.6]; Sulfotransferase family [PF13469.8, score=29.1]} {Human: ENSG00000196228, SULT1C3, sulfotransferase family 1C member 3, [Score=119, Expect=8e-31]; ENSG00000197165, SULT1A2, sulfotransferase family 1A member 2, [Score=118, Expect=1e-30]; ENSG00000138068, SULT6B1, sulfotransferase family 6B member 1, [Score=118, Expect=2e-30]; ENSG00000198203, SULT1C2, sulfotransferase family 1C member 2, [Score=115, Expect=2e-29]} {Mouse: ENSMUSG00000038045, Sult6b1, sulfotransferase family, cytosolic, 6B, member 1, [RH, Score=125, Expect=2e-33]} {Dmel: FBgn0037665, St2, Sulfotransferase 2, [Score=108, Expect=5e-27]} {Celegans: WBGene00013748, ssu-1, Suppressor of Stomatin mutant Uncoordination, [Score=109, Expect=5e-27]} {Smed: dd_Smed_v6_38079_0_1, dd_Smed_v6_38079_0_1, [Score=102, Expect=3e-25]} {RNA1509_50382, RNA1509_59532} {RNA1310_7046.1, RNA1509_50382, RNA1509_59532} {RNA1509_50382, RNA1509_59532, RNA815_2250.1}
35. MligTC455_56421 59 1.23 Mlig455_066824

Neo: -

Age: -

0.953 - - - 0.953 - - Mlig455_066824 {REF} {Length: 413} {RNA1509_38728} {RNA1310_9789} {RNA815_21216}
36. MligTC455_41020 603 12.57 Mlig455_032493

Neo: -

Age: Up-Down-Down

SGSM1 0.951 - - - 0.951 - - Mlig455_032493 {REF} {Length: 5426} {Pfam: Rab-binding domain (RBD) [PF12068.10, score=113.2]; Rab-GTPase-TBC domain [PF00566.20, score=99.4]; RUN domain [PF02759.21, score=68.0]} {Human: ENSG00000167037, SGSM1, small G protein signaling modulator 1, [Score=369, Expect=4e-109]} {Mouse: ENSMUSG00000038351, Sgsm2, small G protein signaling modulator 2, [Score=464, Expect=3e-145]} {Dmel: FBgn0052506, CG32506, [Score=283, Expect=1e-78]} {Celegans: WBGene00008018, tbc-8, TBC (Tre-2/Bub2/Cdc16) domain family, [Score=214, Expect=3e-58]} {Smed: dd_Smed_v6_3307_0_1, dd_Smed_v6_3307_0_1, [Score=394, Expect=7e-119]} {RNA1509_23023} {RNA1310_13249.1} {RNA815_3765}

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